Ectopic posterior pituitary gland

Case contribution: Dr. Raja Rizal Azman


  • A 10-year old girl presents with short stature secondary to Growth Hormone deficiency.
  • She was born at term with no complications during delivery.
  • She achieved all her developmental milestones normally.
  • Apart from short stature there were no physical abnormalities on physical examination.

MRI findings:

  • T1-weighted sagittal image showing a focal hyperintense lesion at the floor of the third ventricle (white arrow).
  • The normal bright stripe of the posterior pituitary in the posterior portion of the sella is absent.
  • There is platybasia of the skull base.
  • The residual pituitary gland within the sella turcica appears hypoplastic.
  • The corpus callosum is preserved.

Diagnosis: Ectopic posterior pituitary with platybasia


  • Ectopic posterior pituitary is a rare condition usually presenting with short stature.
  • The location of the ectopic posterior pituitary is commonly at the median eminence at the base of the third ventricle.
  • Ectopic posterior pituitary can be isolated or associated with numerous other conditions such as septo-optic dysplasia, platybasia, Chiari 1 malformation, corpus callosum dysgenesis, and Kallman syndrome.
  • Careful evaluation of the MRI including thin slices of the midline and contrast enhanced images should be made to look for other abnormalities of the brain.
  • The association with numerous other congenital midline abnormalities suggests a possible common underlying genetic aetiology.


Author: radhianahassan