Invasive breast carcinoma of non-specific type

Case contribution: Dr Radhiana Hassan


  • A 59 years old came for screening mammogram
  • Had mammogram done 3 years ago was normal
  • No family history of breast cancer
Bilateral mammogram in MLO views
Bilateral mammogram in CC views

Mammogram findings:

  • Bilateral fatty breasts (BIRADS A)
  • An area of focal density with stromal distortion at lower inner quadrant of right breast (red circle)
  • No suspicious clustered microcalcification
  • No skin thickening or nipple retraction
Ultrasound of right breast

Ultrasound findings:

  • An ill-defined hypoechoic lesions at Rt5-6H
  • The lesion shows significant posterior shadowing
  • No ductal dilatation
  • No abnormal axillary nodes

Progress of patient:

  • Trucut biopsy done shows infiltrating ductal carcinoma.
  • Right mastectomy and axillary clearance done
  • DCIS component seen, no vascular invasion, no LNs involvement (20 LN removed), ER/PR +ve and HER2 +1
  • Impression: Invasive carcinoma of nonspecific type Grade 1 (T1MoNx)

Diagnosis: Breast carcinoma: invasive nonspecific type


  • Invasive carcinoma of no special type (NST) also known as invasive ductal carcinoma or ductal NOS and previously known as invasive ductal carcinoma, not otherwise specified (NOS)
  • It is a group of breast cancers that do not have the “specific differentiating features”.
  • It is the most common form of invasive breast cancer. It accounts for 55% of breast cancer incidence upon diagnosis.
Author: radhianahassan