Germ cell tumour of the liver

Case contribution: Dr Radhiana Hassan

Clinical:

  • A 33 years old male
  • History of traumatic pancreatitis, treated and resolved
  • Presented with acute epigastric pain about 11 months later
  • Not relieved with painkiller, associated with vomiting
  • No fever, no URTI symproms
  • No altered bowel habit 
  • Serum amylase is normal, LFT deranged

Abdominal radiograph findings:

  • No obvious mass lesion is seen
  • Normal bowel loops, no bowel dilatation
  • Psoas shadows are seen bilaterally
  • Bones and soft tissues are unremarkable
Ultrasound of hepatobiliary system

Ultrasound findings:

  • There are heterogenous lesions predominantly located at the peripheral aspect of the right lobe. The main bulk of the lesion appears vague with ill-defined border, but some parts of the lesion are echogenic and more well-defined.
  • The branch of the portal vein supplying this part of the liver appears to contain echogenic thrombus, with vascularity observed at the periphery of the vein on Doppler interrogation.
  • Vascularity is still seen within the affected segments of the liver.
  • Another much smaller ill-defined hypoechoic lesion is also seen in segment III of the liver, also located peripherally.
  • The main portal vein (1.0cm) also appears unremarkable.
  • The pancreatic duct is dilated measuring 0.5cm. The pancreatic parenchyma itself appears unremarkable with no focal pancreatic lesion seen.
  • Spleen is homogenous and normal in size.
Multiphase CT liver in axial planes soft tissue window

 

CT scan findings:

  • Liver is enlarged; with its craniocaudal length measures about 15.8cm. ┬áLiver margin is however smooth.
  • Liver parenchyma appears heterogeneously enhanced with multiple lesions within which were not seen on previous CT done about 11 months ago.
  • There are multiple ill-defined hypodense areas seen in both liver lobes (mainly at right lobe of liver). Its mean HU is about 37 on plain, with mild enhancement on both arterial and portovenous phase (mean HU about 60).
  • The largest is at segment VI measures about 7.7 x 9.0 x 9.3cm (AP x W x CC) and VIII of liver, measures about 4.5 x 8.4 x 7.1cm (AP x W x CC).
  • Long segment filling defect is seen within the posterior branch of right portal vein and left portal vein suggestive of portal vein thrombosis. These areas showed early enhancement on the arterial phase, suggestive of compensatory supply from the hepatic arteries, in view of the portal vein thrombosis.
  • No apparent filling defect seen within other branches of portal vein or IVC.
  • Main portal vein is not dilated, measures about 1.2cm.

HPE findings:

  • Macroscopy: liver specimen consists of multiple pieces of greyish tissue submitted in one block
  • Microscopy: sections show fragments of fibrocollagenous tissues with sheets of malignant cells infiltration. The malignant cells display moderate pleomorphic nuclei, hyperchromatic to vesicular nuclei with some shows prominent nucleoli. Mitosis are easily seen including abnormal form. In areas, necrosis are present. There are small fragments of benign skin tissue and muscular tissue included
  • Immunohistochemical studies show the malignant cells are CK7, CK20 and alpha fetoprotein positive. Hep Par1 and TTF1 are negatives.
  • Interpretation: Germ cell tumour

Diagnosis: Primary germ cell tumour of the liver

Discussion:

  • Most germ cell tumours develop in gonads
  • However, the germ cells can be misplaced during embryogenesis, thus these tumours can arise in numerous extragodanal sites including the hepatobiliary system.
  • Germ cell tumour of the liver is extremely rare

 

Author: radhianahassan